Greetings, Reverse: 1999 players! Today we bring the ultimate Poison DPS for Poison teams, Ramona, the newest 6★ Plant Afflatus character. She dominates battles by stacking Poison and unleashing devastating Expellant explosions for massive Genesis damage. And if you are looking for a better way to build her and dominate the battles with the meta Poison teams, this Reverse: 1999 Ramona build guide will help you master her gameplay, teams, and damage rotations more easily.

Building Ramona efficiently in Reverse: 1999 turns her into a powerhouse Poison carry, but it requires a lot of farming through stages, daily quests, and upgrade materials. This can take more time if you do it manually. To make farming easier, you can use OSLink. It offers a multi-instance manager that lets you run multiple game instances and use auto-click setups or scripts for repetitive tasks like farming, daily runs, and resource collection. This helps you save time, progress faster, and upgrade Ramona more efficiently with less manual effort.

Ramona: Overview

Ramona is a powerful 6★ Plant Afflatus character who focuses on overwhelming enemies with deadly poison effects. She excels at applying poison stacks and converting them into a stronger state called Expellant, allowing her to deal massive Genesis DoT damage throughout battles.

The biggest strength that makes Ramona stand out is her ability to repeatedly trigger poison effects, causing enemies to take continuous damage even after her turn ends. Because of this, she performs exceptionally well as a main DPS in both boss fights and multi-wave content.

Ramona is also a flexible team member who fits into many team compositions, especially in long battles where poison damage can fully build up. Even at base investment, she can deal strong and consistent damage, but her performance becomes even better when paired with teammates that can support and enhance poison effects.

Ramona Core Mechanic: Poison & Exorcist-for-Hire

Ramona's playstyle revolves around stacking powerful poison effects and turning them into massive Genesis damage.

Poison & Expellant

• Ramona can apply strong Poison stacks to enemies, dealing continuous Genesis damage over time.

• Her Ultimate is the core of her kit, as it converts up to 6 Poison stacks into a stronger effect called Expellant.

• Once activated, Expellant deals heavy Genesis damage over multiple rounds and ends with a powerful final burst. The longer it stays active, the more damage it can deal.

Exorcist-for-Hire Mechanic

Ramona also uses a special mechanic called Exorcist-for-Hire to trigger extra poison damage:

• She gains Exorcist-for-Hire stacks during battle.

• These stacks can apply Possess to her Incantation cards.

• When a Possessed card is played, Ramona activates Merry Gold Method, which applies more Poison and Spirit Repellent to enemies.

• Spirit Repellent can stack up to 6 times and causes all Poison effects to trigger an additional time at the end of each round.

Your Goal: You have to build 6+ Poison stacks, convert them with her Ultimate, and then keep triggering everything with her skills and follow-up attacks for continuous explosions of damage.

Ramona Kit Breakdown

Before entering battles with this Poison DPS character, Ramona, you need to understand her kit, including Ramona Arcane Skills and ultimate to maximize the advantage of using her in your battles:

Ramona Inheritance Effects

Ramona’s Inheritance skills help boost Poison application, improve Spirit Repellent and Possess triggers, and support smooth Moxie generation, making her gameplay more consistent and explosive.

Ramona Portraits

Ramona’s Portraits help build her into a strong Poison-focused DPS in Reverse: 1999. Her portraits boost overall damage, Poison application, follow-ups, and Expellant power. Here are the details:

Recommendations: Even at P0, Ramona is completely playable and strong. Prioritize P1 as a strong general upgrade. Then P2 and P5 for major Poison scaling power spikes.

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Best Psychubes for Ramona 

When you are going for the Reverse: 1999 Ramona best build, choosing the right Psychubes is a major advantage. So, focus on Psychubes that offer Genesis DMG, ATK, Crit, and follow-up synergy because her damage comes heavily from Poison detonations:

Ramona Resonance Priority Tip: Focus heavily on ATK% to increase all her Poison and Genesis damage. Sub-stats like Crit Rate, Crit DMG, or Mental DMG are good secondary choices for extra damage.

Ramona Best Team Compositions

With a proper Reverse: 1999 Ramona build, she becomes the main Poison-applying DPS in your team, making her a meta choice for Poison-focused setups. She needs supports that amplify Poison application, provide AP/Moxie economy, enable strong follow-ups, and offer sustain for consistent detonations. Below are the best team compositions for Ramona:

Meta Poison Team (Optimal) 

This Ramona team is the best Poison team where Ramona acts as the main damage dealer. Willow and Tuesday greatly increase Poison stacks and overall team damage, while Marsha keeps the team alive. Together, they create fast, high-detonation turns that melt bosses safely and clear groups of enemies easily.

Mental - Poison Flex Team 

This is a budget-friendly Ramona team focused on triggering consistent Poison effects and dealing strong Mental damage alongside Ramona. It synergizes well with her Poison detonations, while Voyager helps with card control and AP economy, and Kiperina provides reliable shielding. This team delivers strong Poison output without heavy investment in characters.

Ramona Gameplay and Playstyle

Ramona R1999 works as a Main DPS in Poison teams. Her main job is to stack strong poison, convert it into powerful Expellant with her Ultimate, and repeatedly trigger all poison effects for massive Genesis damage. She also deals decent direct damage, but her real strength comes from consistent poison application and frequent detonations.

Ramona gameplay is straightforward once you learn her rotation. At the start of each round she gains Exorcist-For-Hire stacks and applies poison to enemies. Focus on building at least 6 poison stacks, then use her Ultimate to turn them into Expellant. Play possessed cards to trigger Merry Gold Method follow-ups, which add Spirit Repellent for extra poison triggers.

During battles, follow her R 2-round rotation: 

• Round 1: Ultimate → Skill 1 → Skill 2

• Round 2: Skill 2 (guaranteed possessed) → Skill 2 or Skill 1

While focusing on rotations make sure to use Skill 2 often to resolve and amplify poison without reducing its duration. Furthermore, pair her with Tuesday to extend Expellant for bigger multipliers and position her in teams where she can make full use of her Mental damage and poison synergy.

Should You Pull Ramona?

Yes, of course. Ramona is worth investing in if you want a strong Poison team. With a proper Reverse: 1999 Ramona build, she makes Poison teams much better and works well as the main carry. However, if you are looking for pull advice for Ramona, consider these facts:

Yes, pull if:

• You already have Tuesday and Willow, so you can complete the meta Poison team for easier battles.

• You need a versatile second or third team for Rivalries or missing Afflatus coverage.

• You’re a mid-game player looking for a reliable team that can hit 10M+ in raids.

• You enjoy sustained poison damage playstyles.

Skip if:

• You don’t have Tuesday (focus on your current teams first).

• You already have a fully built roster covering all content.

Conclusion

That’s everything you need to know about Ramona from this ultimate Reverse: 1999 Ramona build guide. Use the tips, best Ramona best builds, best teams, Psychubes, and rotation methods above to build her easily and improve her Poison damage in battles. To make farming faster and easier, you can also use OSLink to help with grinding and resource collection, so you can upgrade Ramona without doing everything manually.