MARVEL Mystic Mayhem Tier List – Best Characters for July 2025

MARVEL Mystic Mayhem is a fast-paced team strategy game where you build squads of heroes and villains to take on PvE, PvP, and raid content. Choosing the right characters with strong synergy is key to winning battles like Eye of Nightmare or climbing the leaderboards. This July 2025 tier list ranks the best picks for damage, survivability, and support, tested at level 30 with max talents and artifacts. Want to level faster or test multiple lineups at once? OSLink lets you automate grinding and manage multiple accounts  at once, so you can focus on what really matters: building your dream roster.

Best S-Tier Characters for PvE and PvP 

S-tier characters are the top picks in the game, offering unmatched power for raids, PvP, and boss fights. Prioritize these heroes when you build a team in MARVEL Mystic Mayhem.

• Iron Man: The best Striker, Iron Man dominates PvP and PvE with AoE and single-target damage that ignores defense. Mana-heavy, so pair with Doctor Strange. Counters: Spider-Man’s debuffs. Soul Saga: Boosts ultimate energy.

• Doctor Strange: Top Controller with healing and debuff removal, perfect for any team. Counters: Scarlet Witch’s burst. Soul Saga: Enhances healing.

• Sentry: Elite Defender for raids and artifact farming, blending high damage and survivability. Counters: Lady Bullseye’s pierce. Soul Saga: Improves damage.

• Armor: Premier tank with taunt and AoE stuns, ideal for raid protection. Counters: Iron Man’s damage. Soul Saga: Stronger shields.

Strong A-Tier Characters for Team Building

A-tier characters are powerful and versatile, excelling with the right synergies or upgrades. Great for most MARVEL Mystic Mayhem content.

• Scarlet Witch: Top Striker for boss fights like Eye of Nightmare, with massive single-target burst. Needs buffs. Counters: Sentry’s health. Soul Saga: Faster resets.

• Thor: Fighter with AoE lightning, strong in PvP and PvE. Vulnerable in melee. Counters: Spider-Man’s debuffs. Soul Saga: Boosts lightning.

• Moon Girl & Devil Dinosaur: Summoner with high summon damage, great for PvE raids. Counters: Iron Man’s AoE. Soul Saga: Stronger summons.

• Emma Frost: Controller with confusion and special damage buffs, key for magical teams. Counters: Thor’s burst. Soul Saga: 50% ultimate energy.

• Juggernaut: Defender with taunt and scaling damage, strong in end-game PvE. Counters: Lady Bullseye’s pierce. Soul Saga: Better shields.

• Lady Bullseye: Striker with single-target damage and assists, great for bosses. Prep-heavy. Counters: Armor’s shields. Soul Saga: Reliable assists.

• Black Knight: Fighter with scaling damage in Berserker Mode, situational. Counters: Spider-Man’s debuffs. Soul Saga: Minimal boost.

• Psylocke: Fighter with burst and assist synergy, solid but outclassed by Thor. Counters: Sentry’s tanking. DISTRICTED Soul Saga: Better assists.

Solid B-Tier Characters for Niche Roles

B-tier characters are reliable in specific scenarios or early-game, but have flaws that limit their impact.

• Dream Queen: Controller who boosts burst windows with ability resets, great with Scarlet Witch. Counters: Thor’s AoE. Soul Saga: More energy.

• Thread: Summoner who directs summons for PvE raids, pairs well with Moon Girl. Counters: Iron Man’s AoE. Soul Saga: Better summon control.

• Spider-Man: Controller with debuffs and assists, useful with Lady Bullseye. Counters: Thor’s burst. Soul Saga: Stronger webbing.

• Storm: Striker with long-range AoE for gold tier PvE, less impactful than Iron Man. Counters: Sentry’s tanking. Soul Saga: Longer debuffs.

• Angela: Defender with crowd control, decent early-game. Counters: Scarlet Witch’s burst. Soul Saga: Better defense buffs.

• Misty Knight: Free-to-play Striker with solid AoE, budget Iron Man. Counters: Armor’s shields. Soul Saga: Stronger ultimate.

• Echo: Fighter with assist synergy, decent for bosses but weaker than Psylocke. Counters: Sentry’s health. Soul Saga: Better assists.

• Moon Knight: Fighter with attack speed buffs, situational in early PvE. Counters: Thor’s damage. Soul Saga: Improved healing.

C-Tier Characters for Early-Game

C-tier characters are viable early-game but struggle in late-game or competitive content.

• Hulk: Defender with health scaling, okay for early PvE but lacks taunt. Counters: Scarlet Witch’s burst. Soul Saga: Better regen.

• Sleepwalker: Starter Controller with basic healing, replaced by Doctor Strange. Counters: Thor’s AoE. Soul Saga: Improved healing.

• Falcon: Controller with minor buffs, niche in physical teams. Counters: Iron Man’s damage. Soul Saga: Longer buffs.

• Doppelganger: Fighter with early-game defense-down utility, falls off later. Counters: Sentry’s tanking. Soul Saga: Cheaper abilities.

D-Tier Characters to Avoid

D-tier characters are the weakest, with minimal impact even in early-game. Use sparingly.

• Man-Thing: Controller with ineffective summons and healing. Counters: Iron Man’s AoE. Soul Saga: Minimal boost.

• Mister Negative: Fighter with weak debuff synergy, not worth investment. Counters: Thor’s burst. Soul Saga: Better self-healing.

Tips to Build the Best Teams in MARVEL Mystic Mayhem

• Summoner Synergy: Pair Moon Girl & Devil Dinosaur with Thread for powerful PvE raid teams.

• Early-Game Heroes: Use Misty Knight or Falcon as budget picks until you unlock S or A-tier characters.

• Maximize Synergies: Team Scarlet Witch with Emma Frost and Dream Queen for devastating boss damage.

• Balance Roles: Include one Defender, one Controller, and one Striker or Fighter for versatile squads.

• Upgrade with Soul Saga: Boost S and A-tier characters with Soul Saga gear for better performance.

• Focus on S-Tier: Iron Man and Doctor Strange are top picks for dominating both PvE and PvP. Having trouble pulling them? Try rerolling with OSLink. Its multi-account manager lets you level up several game instances on your PC at once, and the built-in auto-clicker can automate repetitive tasks like early campaign stages. It’s an efficient way to fast-track your progress and find the best account to invest in.

Conclusion

This July 2025 MARVEL Mystic Mayhem tier list highlights the best characters to dominate PvE and PvP. Prioritize S-tier heroes like Iron Man and Doctor Strange, and experiment with A-tier picks like Scarlet Witch for specific strategies.And if you want to level up multiple accounts, automate farming, or test new lineups without grinding for hours, OSLink makes it effortless. Build your ultimate team, and rule the battlefield smarter.